Hazard of recurrence and adjuvant treatment effects over time in lymph node-negative breast cancer

@article{Dignam2008HazardOR,
  title={Hazard of recurrence and adjuvant treatment effects over time in lymph node-negative breast cancer},
  author={James J. Dignam and Vanja Dukic and Stewart J. Anderson and Eleftherios P Mamounas and Donald Lawrence Wickerham and Norman Wolmark},
  journal={Breast Cancer Research and Treatment},
  year={2008},
  volume={116},
  pages={595-602}
}
Background For patients with axillary lymph node-negative breast cancer, benefits from adjuvant therapy are smaller than in node-positive disease and thus more selective use is warranted, prompting development of risk profiling to identify those most likely to benefit. Examination of the magnitude and changes in the hazard of failure over time in node-negative breast cancer may also be informative in this regard. Methods Among 9,444 participants from five randomized trials (accrual 1982–1998… CONTINUE READING