Hayflick, his limit, and cellular ageing

  title={Hayflick, his limit, and cellular ageing},
  author={Jerry W. Shay and Woodring E. Wright},
  journal={Nature Reviews Molecular Cell Biology},
  • J. Shay, W. Wright
  • Published 1 October 2000
  • Biology
  • Nature Reviews Molecular Cell Biology
Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent — a phenomenon now known as the ‘Hayflick limit’. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing. 

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