Hax1 regulates neutrophil adhesion and motility through RhoA

@inproceedings{Cavnar2011Hax1RN,
  title={Hax1 regulates neutrophil adhesion and motility through RhoA},
  author={Peter J. Cavnar and Erwin Berthier and David J. Beebe and Anna Huttenlocher},
  booktitle={The Journal of cell biology},
  year={2011}
}
Kostmann disease is an inherited severe congenital neutropenia syndrome associated with loss-of-function mutations in an adaptor protein HS1-associated protein X-1 (Hax1). How Hax1 regulates neutrophil function remains largely unknown. In this paper, we use ribonucleic acid interference to deplete Hax1 in the neutrophil-like cell line PLB-985 and identify… CONTINUE READING