Have Treatment Studies of Depression Become Even Less Generalizable? A Review of the Inclusion and Exclusion Criteria Used in Placebo-Controlled Antidepressant Efficacy Trials Published During the Past 20 Years.


OBJECTIVE To compare the inclusion and exclusion criteria used in antidepressant efficacy trials (AETs) published during the past 5 years with those used in studies published during the previous 15 years. PATIENTS AND METHODS We conducted a comprehensive literature review of placebo-controlled AETs published from January 1995 through December 2014. We… (More)
DOI: 10.1016/j.mayocp.2015.06.016


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