Hath1 up-regulates gastric mucin gene expression in gastric cells.

  title={Hath1 up-regulates gastric mucin gene expression in gastric cells.},
  author={Akiko Sekine and Yoshimitsu Akiyama and Kazuyoshi Yanagihara and Yasuhito Yuasa},
  journal={Biochemical and biophysical research communications},
  volume={344 4},
The Notch signaling pathway is known to mediate the differentiation and fate specification of cells in embryonic stage and adult tissues. Several tumors exhibit aberrant expression of Notch signaling component genes, such as Notch1/2/3 and Hath1. In this study, we investigated the mRNA expression of seven Notch-related genes, Notch1/2/3, Hes1/2/3, and Hath1, and then compared it with the expression of gastric mucin genes, MUC5AC and MUC6, in eight gastric cancer (GC) cell lines. Notch1/2/3 and… CONTINUE READING
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