Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells.

@article{Leow2004Hath1DI,
  title={Hath1, down-regulated in colon adenocarcinomas, inhibits proliferation and tumorigenesis of colon cancer cells.},
  author={Ching Ching Leow and Mar{\'i}a Soledad Romero and Sarajane Ross and Paul Polakis and Wei-Qiang Gao},
  journal={Cancer research},
  year={2004},
  volume={64 17},
  pages={6050-7}
}
A striking feature of colon tumors is the significant reduction of goblet cells. Although targeted deletion of Math1 in mice leads to a loss of intestinal secretory cells, including goblet cells, the role of Hath1 in colon tumorigenesis remains unknown. Here we report that Hath1, the human ortholog of Math1, was dramatically down-regulated in colon tumor samples and colon cancer cell lines. Overexpression of Hath1 in HT29, an aggressive colon cancer cell line, resulted in a significant… CONTINUE READING
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