Hastatoside and verbenalin are sleep-promoting components in Verbena officinalis

  title={Hastatoside and verbenalin are sleep-promoting components in Verbena officinalis},
  author={Yukiko Makino and Shino Kondo and Yoshiko Nishimura and Yoshinori Tsukamoto and Zhi-Li Huang and Yoshihiro Urade},
  journal={Sleep and Biological Rhythms},
Herbal tea made from Verbena officinalis (V. officinalis) has traditionally been used for the treatment of insomnia and other nervous conditions. In this study, we examined the sleep-promoting activity of hastatoside, verbenalin, and verbascoside, which are the major iridoids (hastatoside and verbenalin) and polyphenol (verbascoside) components responsible for the pharmacological activity of V. officinalis, by electroencephalographic analysis of rats after oral administration of the compounds… Expand
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Verbena officinalis (Common Vervain) - A Review on the Investigations of This Medicinally Important Plant Species.
Traditional medicinal uses and professional pharmacological in vitro and in vivo studies that prove new important applications, e.g., antioxidant, antimicrobial, anti-inflammatory, neuroprotective anticancer, analgesic, or anticonvulsant of verbena herb extracts and individual metabolites are summarized. Expand
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Simultaneous quantification of verbenalin and verbascoside in Verbena officinalis by ATR-IR and NIR spectroscopy.
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Two new iridoids, 3-(5-(methoxycarbonyl)-2-oxo-2H-pyran-3-yl)butanoic acid, named verbeofflin I and 7-hydroxydehydrohastatoside, were isolated from the aerial part of Verbena officinalis L, along with three known iridoid, verbenalin, by means of various column chromatography steps. Expand
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Hypnotic effects of total aqueous extracts of Vervain hastata (Verbenaceae) in rats
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Quantitative determination of the major constituents of Verbena officinalis using high performance thin layer chromatography and high pressure liquid chromatography.
A pentacyclic triterpenoid, ursolic acid (1), two iridoid glucosides, verbenalin (2) and hastatoside (3), and a phenylpropanoid glycoside, verbascoside (4), were isolated from Verbena officinalisExpand
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Hastatosid, ein neues Iridoid aus Verbena hastata L. und Verbena officinalis L. [1] / Hastatoside, a New Iridoid from Verbena hastata L. and Verbena officinalis L. [1]
Verbenalin and a new iridoid, hastatoside, have been isolated from Verbena hastata and V. officinalis and the lactone 7 has been synthesized from verbenaline. Expand
Arousal effect of orexin A depends on activation of the histaminergic system
  • Z. L. Huang, W. Qu, +5 authors O. Hayaishi
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2001
Findings strongly indicate that the arousal effect of orexin A depends on the activation of histaminergic neurotransmission mediated by H1R. Expand
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