Hassles with Taking Out the Garbage: Aggravating Aggresomes

@article{GarcaMata2002HasslesWT,
  title={Hassles with Taking Out the Garbage: Aggravating Aggresomes},
  author={R. Garc{\'i}a-Mata and Ya-sheng Gao and E. Sztul},
  journal={Traffic},
  year={2002},
  volume={3}
}
Diverse human diseases ranging from amyloidosis to neurodegenerative diseases are now recognized as ‘conformational diseases’ caused by protein misfolding and protein aggregation. Misfolded and aggregated proteins are usually handled in the cell through chaperone‐mediated refolding, or when that is impossible, destroyed by proteasomal degradation. Recent evidence suggests that cells might have evolved a third pathway that involves the sequestration of aggregated proteins into specialized… Expand
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