Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

@article{Watanabe2005HassallsCI,
  title={Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus},
  author={Norihiko Watanabe and Yi-hong Wang and Heung Kyu Lee and Tomoki Ito and Ying Wang and Wei Cao and Yong-Jun Liu},
  journal={Nature},
  year={2005},
  volume={436},
  pages={1181-1185}
}
Hassall's corpuscles—first described in the human thymus over 150 years ago—are groups of epithelial cells within the thymic medulla. The physical nature of these structures differs between mammalian species. Although Hassall's corpuscles have been proposed to act in both the removal of apoptotic thymocytes and the maturation of developing thymocytes within the thymus, the function of Hassall's corpuscles has remained an enigma. Here we report that human Hassall's corpuscles express thymic… CONTINUE READING
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Recognition of the peripheral self by naturally arising CD4þCD25þ T cell receptors

  • Hsieh, C.-S
  • Immunity 21,
  • 2004

receptor-controlled checkpoints in T-cell development

  • von Boehmer, H. Selection of the T-cell repertoire
  • Adv. Immunol. 84, 201–-238
  • 2004

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