Haspin: a newly discovered regulator of mitotic chromosome behavior

  title={Haspin: a newly discovered regulator of mitotic chromosome behavior},
  author={Jonathan M. G. Higgins},
The haspins are divergent members of the eukaryotic protein kinase family that are conserved in many eukaryotic lineages including animals, fungi, and plants. Recently-solved crystal structures confirm that the kinase domain of human haspin has unusual structural features that stabilize a catalytically active conformation and create a distinctive substrate binding site. Haspin localizes predominantly to chromosomes and phosphorylates histone H3 at threonine-3 during mitosis, particularly at… CONTINUE READING


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