Hashimoto’s Thyroiditis: History and Future Outlook

@article{Hiromatsu2013HashimotosTH,
  title={Hashimoto’s Thyroiditis: History and Future Outlook},
  author={Yuji Hiromatsu and Hiroshi Satoh and Nobuyuki Amino},
  journal={Hormones},
  year={2013},
  volume={12},
  pages={12-18}
}
Dr. Hakaru Hashimoto (Figure 1), born 5 May 1881, was the third son of a prominent family who had practiced medicine for generations in Iga Ueno, Mie Prefecture, Japan. [...] Key Result Hakaru Hashimoto further explained in his report that the new pathological characteristics he had identified, namely infiltration of lymphoid and plasma cells, formation of lymphoid follicles with germinal centers, fibrosis, degenerated thyroid epithelial cells and leukocytes in the lumen, were histologically similar to those of…Expand
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Classical ultrasound imaging of Hashimoto’s thyroiditis shows: enlarged gland, diffusely heterogeneous, coarse echotexture, multiple hypoechoic micronodules ranging from 1 to 6 mm in diameter and coarse septations from fibrous bands and microlobulated margin. Expand
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An association between Hashimoto’s thyroiditis (HT) and papillary, follicular, medullary, anaplastic thyroid carcinoma, and thyroid lymphoma (TL) is found and an association between HT and PTC and betweenHT and TL is reported. Expand
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The focus is on the presentation of disease, pathophysiology and diagnostic difficulties with analysis of modern literature on chronic lymphocytic thyroiditis. Expand
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Clinical and histopathologic feature of the disease includes lymphoplasmacytic infiltration, lymphoid follicle formation with germinal centers, and parenchymal atrophy; thus, a T and B cells inflammatory infiltration is frequently found in Hashimoto's thyroiditis. Expand
The Impact of Hashimoto Thyroiditis on Thyroid Nodule Cytology and Risk of Thyroid Cancer
TLDR
HT increases the risk of thyroid malignancy in any patient presenting for nodule evaluation, and Diffuse sonographic heterogeneity and/or TPOAb positivity should be used for risk assessment at time of evaluation. Expand
The Pathogenesis of Hashimoto's Thyroiditis: Further Developments in our Understanding.
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  • Medicine
  • Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
  • 2015
TLDR
Despite the large number of studies, the mechanistic pathways in HT are still not fully understood and further work is required to enhance knowledge and identify novel preventative and therapeutic clinical targets. Expand
The importance of nutritional factors and dietary management of Hashimoto's thyroiditis.
TLDR
The article describes the nutrition factors of Hashimoto's patients, and share nutrition recommendations for diet therapy, and indicates the proper level of protein intake, dietary fibre and unsaturated fatty acids. Expand
Ultrasonography in the diagnosis of Hashimoto's thyroiditis.
TLDR
The recent advantages of ultrasonography in the diagnosis of Hashimoto's thyroiditis are discussed and non-invasive ultrasound-based methods have supplemented fine-needle aspiration to diagnose Hashimoto’s thyroiditis under more complex conditions. Expand
Analysis of Hashimoto's thyroiditis on fine needle aspiration samples by MALDI-Imaging.
TLDR
The possibility to overlap the molecular signatures of both the lymphocytes and epithelial cells components (ROIs or pixel by pixel analysis) confirmed the composite proteomic background of HT and open the way to their possible translation as alternative serum biomarkers of this autoimmune condition. Expand
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HT is frequently associated with papillary thyroid carcinoma and may indeed be a risk factor for developing this type of cancer and the relationship between thyroid lymphoma and HT on the other hand appears well established. Expand
Clinical relationship between Hashimoto's thyroiditis and papillary thyroid cancer
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Interestingly, the coexistence of HT in PTC cases introduced favourable clinical outcomes compared with those of PTC without HT, and PTC with HT patients exhibited better prognosis during the 62-month mean follow-up period. Expand
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The fibrous variant ofHashimoto's thyroiditis presents a clinicopathologic picture quite distinct from that of typical Hashimoto's disease, and may be mistaken for cancer with islands of metaplastic epithelium in the fibrotic tissue simulating foci of carcinoma cells. Expand
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People with Hashimoto's thyroiditis have serum antibodies reacting with TG, TPO, and against an unidentified protein present in colloid, and many patients have cell mediated immunity directed against thyroid antigens, demonstrable by several techniques. Expand
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Hashimoto's Thyroiditis: From Genes to the Disease
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Hashimoto’s thyroiditis (HT) is the most prevalent autoimmune thyroid disorder and the attention is focused predominantly on female sex, pregnancy with postpartum period and fetal microchimerism. Expand
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Clinical awareness of the characteristic presentations of Riedel's thyroiditis should enhance the ability to make this diagnosis in a timely and focused manner and result in enhanced diagnostic and therapeutic tools in the future. Expand
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The identification of IgG4-RD of the thyroid gland opens new insights not only for patient's treatment with HT but also for the development of new therapeutic approaches for this rapidly progressive destructive subtype of HT. Expand
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