Has the microbiota played a critical role in the evolution of the adaptive immune system?

@article{Lee2010HasTM,
  title={Has the microbiota played a critical role in the evolution of the adaptive immune system?},
  author={Yun Kyung Lee and S K Mazmanian},
  journal={Science},
  year={2010},
  volume={330 6012},
  pages={1768-73}
}
Although microbes have been classically viewed as pathogens, it is now well established that the majority of host-bacterial interactions are symbiotic. During development and into adulthood, gut bacteria shape the tissues, cells, and molecular profile of our gastrointestinal immune system. This partnership, forged over many millennia of coevolution, is based on a molecular exchange involving bacterial signals that are recognized by host receptors to mediate beneficial outcomes for both microbes… CONTINUE READING
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  • J. L. Round, S. K. Mazmanian
  • Natl. Acad. Sci. U.S.A. 107,
  • 1220
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