Has the code for protein translocation been broken?

  title={Has the code for protein translocation been broken?},
  author={Dalit Shental-Bechor and Sarel Jacob Fleishman and Nir Ben-Tal},
  journal={Trends in biochemical sciences},
  volume={31 4},
Polypeptides chains are segregated by the translocon channel into secreted or membrane-inserted proteins. Recent reports claim that an in vivo system has been used to break the "amino acid code" used by translocons to make the determination of protein type (i.e. secreted or membrane-inserted). However, the experimental setup used in these studies could have confused the derivation of this code, in particular for polar amino acids. These residues are likely to undergo stabilizing interactions… CONTINUE READING

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