Harzianums A and B produced by a fungal strain, Hypocrea sp. F000527, and their cytotoxicity against tumor cell lines.

@article{Jin2007HarzianumsAA,
  title={Harzianums A and B produced by a fungal strain, Hypocrea sp. F000527, and their cytotoxicity against tumor cell lines.},
  author={H Jin and J-H Lee and W Zhang and H-B Lee and Y-S Hong and Y H Kim and J J Lee},
  journal={Journal of Asian natural products research},
  year={2007},
  volume={9 3-5},
  pages={203-7}
}
A new compound, harzianum B (1), was isolated from the culture broth of a fungal strain, Hypocrea sp. F000527, together with a known trichothecene, harzianum A (2). Its structure was determined by spectroscopic analyses including HRFAB-MS and various (1)H NMR and (13)C NMR spectral data. Harzianum B (1) was characterised as (E,Z,E)-2', 4', 6'-octatriendioic acid esterified on the 4beta-hydroxyl group of trichodermol. Harzianums A (2) and B (1) showed cytotoxicity against several human cancer… CONTINUE READING

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