Harvey ras Results in a Higher Frequency of Mammary Carcinomas than Kirsten ras after Direct Retro viral Transfer into the Rat Mammary Gland1

Abstract

Exclusive activation of either the Harvey-, Kirsten-, or N-ros gene is often found in human and rodent cancers, although the mechanisms responsible for tissue-specific ras gene activation are poorly understood. In this study, the contribution of ras gene expression and Ras protein activity to the tissue-specificity of ras gene activation was investigated… (More)

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