Harry M. Vars Research Award. A new model to determine in vivo the relationship between amino acid transmembrane transport and protein kinetics in muscle.

@article{Biolo1992HarryMV,
  title={Harry M. Vars Research Award. A new model to determine in vivo the relationship between amino acid transmembrane transport and protein kinetics in muscle.},
  author={Gianni Biolo and David L. Chinkes and Xiao-jun Zhang and Robert R. Wolfe},
  journal={JPEN. Journal of parenteral and enteral nutrition},
  year={1992},
  volume={16 4},
  pages={305-15}
}
The bidirectional transmembrane transport rates of leucine (Leu), valine (Val), phenylalanine (Phe), lysine (Lys), and alanine (Ala) were measured in vivo in the hindlimb muscle of five dogs and related to the rates of protein synthesis and degradation. The compartmental model was based on the systemic continuous infusion of stable isotopic tracers of the amino acids, and the measurement of the enrichment and concentration in the arterial and femoral vein plasma and the intracellular free water… CONTINUE READING

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