Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line.

@article{Schmitt2016HarnessingTT,
  title={Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line.},
  author={Mathieu Schmitt and Benjamin Dehay and Erwan B{\'e}zard and F Javier Garcia-Ladona},
  journal={Synapse},
  year={2016},
  volume={70 3},
  pages={71-86}
}
The identification of an effective disease-modifying treatment for the neurodegenerative progression in Parkinson's disease (PD) remains a major challenge. Epidemiological studies have reported that intake of statins, cholesterol lowering drugs, could be associated to a reduced risk of developing PD. In-vivo studies suggest that statins may reduce the severity of dopaminergic neurodegeneration. The trophic potential of statins and their impact on the expression of dopaminergic synaptic markers… CONTINUE READING