Harnessing the oxidation susceptibility of deubiquitinases for inhibition with small molecules.

Abstract

Deubiquitinases (DUBs) counteract ubiquitination by removing or trimming ubiquitin chains to alter the signal. Their diverse role in biological processes and involvement in diseases have recently attracted great interest with regard to their mechanism and inhibition. It has been shown that some DUBs are regulated by reactive oxygen species (ROS) in which… (More)
DOI: 10.1002/anie.201408411

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