Harnessing regulatory T cells for clinical use in transplantation: the end of the beginning.

@article{Juvet2014HarnessingRT,
  title={Harnessing regulatory T cells for clinical use in transplantation: the end of the beginning.},
  author={Stephen C. Juvet and Andrew Whatcott and Andrew R. Bushell and Kathryn J. Wood},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2014},
  volume={14 4},
  pages={750-63}
}
Owing to the adverse effects of immunosuppression and an inability to prevent chronic rejection, there is a pressing need for alternative strategies to control alloimmunity. In three decades, regulatory T cells (Tregs) have evolved from a hypothetical mediator of adoptively transferred tolerance to a well-defined population that can be expanded ex vivo and returned safely to patients in clinical trials. Herein, we review the historical developments that have permitted these advances and the… CONTINUE READING

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A clinical trial of regulatory T cell-based immunotherapy for tolerance induction in living donor liver transplantation

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