Harnessing neuroplasticity: modern approaches and clinical future

@article{Sasmita2018HarnessingNM,
  title={Harnessing neuroplasticity: modern approaches and clinical future},
  author={Andrew Octavian Sasmita and Joshua Kuruvilla and Anna Pick Kiong Ling},
  journal={International Journal of Neuroscience},
  year={2018},
  volume={128},
  pages={1061 - 1077}
}
ABSTRACT Background and purpose: Neurological diseases and injuries to the nervous system may cause inadvertent damage to neuronal and synaptic structures. Such phenomenon would lead to the development of neurological and neurodegenerative disorders which might affect memory, cognition and motoric functions. The body has various negative feedback systems which can induce beneficial neuroplastic changes in mediating some neuronal damage; however, such efforts are often not enough to ameliorate… 

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References

SHOWING 1-10 OF 192 REFERENCES

Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons.

The present findings suggest that enhanced neurogenesis and synaptogenesis by bilobalide and quercetin may share a common final signaling pathway mediated by phosphorylation of CREB.

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

A cell-specific and region-specific gene expression approach was used to determine gene expression changes in astrocytes in the most widely used MS model, experimental autoimmune encephalomyelitis (EAE), and this provides proof-of-concept that a cell- Specific and Region-specificGene expression approach can provide potential treatment targets in distinct neuroanatomic regions during multifocal neurological diseases.

Inflammation Triggers Synaptic Alteration and Degeneration in Experimental Autoimmune Encephalomyelitis

In experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis, inflammation is capable in enhancing glutamate transmission in the striatum and in promoting synaptic degeneration and dendritic spine loss, and EAE-induced synaptopathy subsided during pharmacological blockade of AMPA receptors.

RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration

It is shown that synapse regeneration is impaired in mouse models of neurodegenerative disease, in association with the failure to induce RBM3, and enhancing cold-shock pathways as potential protective therapies in neurodegenersative disorders is supported.

Mechanism of Oxidative Stress and Synapse Dysfunction in the Pathogenesis of Alzheimer’s Disease: Understanding the Therapeutics Strategies

It is suggested that oxidative stress mediated through NMDAR and their interaction with other molecules might be a driving force for tau hyperphosphorylation and synapse dysfunction.

Activation of Wnt signaling promotes hippocampal neurogenesis in experimental autoimmune encephalomyelitis

It is found that Wnt signaling is transiently upregulated in the acute stage of disease, consistent with a timely induction of canonical Wnt ligands, and raised the possibility that enhancement of WNT signaling may support neurogenic processes to cope with neuronal deficits upon immune-mediated neuroinflammation.

Adult Neuroplasticity: More Than 40 Years of Research

Several aspects of neuroplasticity are reviewed and the functional implications of the Neuroplastic capacities of the adult and differentiated brain with reference to the history of their discovery are discussed.

Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides

It is possible that giving uridine plus DHA triggers a neuronal program that, by accelerating phosphatide and synaptic protein synthesis, controls synaptogenesis, and this treatment may ameliorate some of the manifestations of the disease.

Neuroprotective effects of ginsenosides on neural progenitor cells against oxidative injury

Among the four ginsenosides, only Rb1 attenuated t-BHP toxicity in the NPCs, and the nuclear factor (erythroizd-derived 2)-like 2/heme oxygenase-1 pathway was found to be key in the intracellular defense against oxidative stress.

Ginsenoside Rd and ginsenoside Re offer neuroprotection in a novel model of Parkinson's disease.

Ginsenosides Rd and Re strongly reduced cell loss and degeneration and significantly protected process lengths and numbers of neurites of TH+ cells, and the anti-oxidative and anti-inflammatory potential of the cellular supernatant was lowered by CCl4 exposure.
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