Harnessing human dendritic cell subsets to design novel vaccines.

  title={Harnessing human dendritic cell subsets to design novel vaccines.},
  author={Jacques Banchereau and Eynav Klechevsky and Nathalie Delieuvin Schmitt and Rimpei Morita and Karolina Anna Palucka and Hideki Ueno},
  journal={Annals of the New York Academy of Sciences},
Dendritic cells (DCs) orchestrate a repertoire of immune responses that endow resistance to infection and tolerance to self. DC plasticity and subsets are prominent determinants of the quality of elicited immune responses. Different DC subsets display different receptors and surface molecules and express different sets of cytokines/chemokines, all of which lead to distinct immunological outcomes. Recent findings on human DC subsets and their functional specialization have provided insights for… CONTINUE READING


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Toll-like receptor 2- dependent induction of vitamin A-metabolizing en- zymes in dendritic cells promotes T regulatory re- sponses and inhibits autoimmunity

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