Harnessing dendritic cells in inflammatory skin diseases

  title={Harnessing dendritic cells in inflammatory skin diseases},
  author={C. Chu and Paola Di Meglio and Frank O. Nestle},
  booktitle={Seminars in immunology},
The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC… CONTINUE READING
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