Harnessing dendritic cells in cancer.

@article{Apetoh2011HarnessingDC,
  title={Harnessing dendritic cells in cancer.},
  author={Lionel Apetoh and Clara Locher and François Ghiringhelli and Guido Kroemer and Laurence Zitvogel},
  journal={Seminars in immunology},
  year={2011},
  volume={23 1},
  pages={42-9}
}
Dendritic cells (DCs) are central to the initiation of tumor-specific immune responses. However, the tumor microenvironment generates immunosuppressive cells and soluble mediators that compromise DC functions and limit the success of DC-based therapies. Progress in understanding DC metabolism in cancer is uncovering novel therapeutic targets that could restore DC capacity to prime T cells and trigger effective anticancer responses. Accumulating evidence also indicates that conventional chemo… CONTINUE READING

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