Harnessing CD1d-restricted T cells toward antitumor immunity in humans.

  title={Harnessing CD1d-restricted T cells toward antitumor immunity in humans.},
  author={Natalia Neparidze and Madhav V Dhodapkar},
  journal={Annals of the New York Academy of Sciences},
Natural killer T (NKT) cells are a distinct subset of T cells that recognize lipid antigens in the context of CD1d molecules. There is a considerable body of evidence implicating a role for NKT cells in regulating antitumor immunity in mice. alpha-Galactosylceramide (alpha-GalCer) is a potent agonist ligand for type I NKT cells. We and others have shown that injection of alpha-GalCer-loaded dendritic cells leads to clear expansion of NKT cells in vivo in cancer patients. Preclinical studies… CONTINUE READING

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