Harmonising the response to DSBs: a new string in the ATM bow.

@article{Lbrich2005HarmonisingTR,
  title={Harmonising the response to DSBs: a new string in the ATM bow.},
  author={Markus L{\"o}brich and Penny A Jeggo},
  journal={DNA repair},
  year={2005},
  volume={4 7},
  pages={
          749-59
        }
}
Ataxia telangiestasia mutated protein (ATM) is the major kinase that initiates the DNA damage signal transduction response following exposure to ionising radiation (IR) in mammalian cells. DNA non-homologous end-joining (NHEJ) is the most significant double strand break (DSB) repair pathway in mammalian cells. ATM-defective cell lines display cell cycle checkpoint defects and show pronounced radiosensitivity. ATM signalling was previously thought to be dispensable for NHEJ. This review… CONTINUE READING

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