Harmonic oscillations in homeostatic controllers: Dynamics of the p53 regulatory system.

@article{Jolma2010HarmonicOI,
  title={Harmonic oscillations in homeostatic controllers: Dynamics of the p53 regulatory system.},
  author={Ingunn W. Jolma and Xiao Yu Ni and Ludger Rensing and Peter Ruoff},
  journal={Biophysical journal},
  year={2010},
  volume={98 5},
  pages={743-52}
}
Homeostatic mechanisms are essential for the protection and adaptation of organisms in a changing and challenging environment. Previously, we have described molecular mechanisms that lead to robust homeostasis/adaptation under inflow or outflow perturbations. Here we report that harmonic oscillations occur in models of such homeostatic controllers and that a close relationship exists between the control of the p53/Mdm2 system and that of a homeostatic inflow controller. This homeostatic control… CONTINUE READING

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