Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways.

@article{Liu2016HarmineIC,
  title={Harmine induces cell cycle arrest and mitochondrial pathway-mediated cellular apoptosis in SW620 cells via inhibition of the Akt and ERK signaling pathways.},
  author={Jiming Liu and Qiang Li and Zhilong Liu and Liuming Lin and Xiangqiang Zhang and Mingrong Cao and Jianwei Jiang},
  journal={Oncology reports},
  year={2016},
  volume={35 6},
  pages={3363-70}
}
Harmine, a β-carboline alkaloid isolated from the seeds of Peganum harmala, possesses both antitumor and anti‑nociceptive effects and inhibits human DNA topoisomerase. However, no detailed data are available concerning the mechanisms of harmine in human colorectal carcinoma SW620 cells. In the present study, we demonstrated that harmine inhibited the… CONTINUE READING