Harmful effects of functional hypercortisolism: a working hypothesis

  title={Harmful effects of functional hypercortisolism: a working hypothesis},
  author={Giacomo Tirabassi and Marco Boscaro and Giorgio Arnaldi},
Functional hypercortisolism (FH) is caused by conditions able to chronically activate hypothalamic–pituitary–adrenal axis and usually occurs in cases of major depression, anorexia nervosa, bulimia nervosa, alcoholism, diabetes mellitus, simple obesity, polycystic ovary syndrome, obstructive sleep apnea syndrome, panic disorder, generalized anxiety disorder, shift work, and end-stage renal disease. Most of these states belong to pseudo-Cushing disease, a condition which is difficult to… CONTINUE READING
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