Haptoglobin polymorphism and schizophrenia: genetic variation on chromosome 16.

  title={Haptoglobin polymorphism and schizophrenia: genetic variation on chromosome 16.},
  author={Michael Maes and Joris Richard Delanghe and Luisella Bocchio Chiavetto and Stefano Bignotti and Gian Battista Tura and Rosaria Pioli and R. A. D. Zanardini and Carlo Alfredo Altamura},
  journal={Psychiatry research},
  volume={104 1},
Recently, it was shown that schizophrenia is accompanied by an activation of the inflammatory response system with signs of an acute phase response, such as increased plasma haptoglobin (Hp) concentrations. Hp is characterized by a molecular variation with three known phenotypes, i.e. Hp 1-1, Hp 2-1 and Hp 2-2. The aim of the present study was to examine Hp phenotypic and genotypic frequencies in schizophrenic patients. Hp phenotyping was carried out in 98 Northwestern Italian schizophrenic… CONTINUE READING


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