Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells.

@article{Graw2016HaptoglobinOH,
  title={Haptoglobin or Hemopexin Therapy Prevents Acute Adverse Effects of Resuscitation After Prolonged Storage of Red Cells.},
  author={J A Graw and Claire Mayeur and Ivy A. Rosales and Yumin Liu and Venkata S. Sabbisetti and Frank E Riley and Osher Rechester and Rajeev Kumar Malhotra and H. Shaw Warren and Robert B. Colvin and Joseph V. Bonventre and Donald B Bloch and Warren M. Zapol},
  journal={Circulation},
  year={2016},
  volume={134 13},
  pages={
          945-60
        }
}
BACKGROUND Extracellular hemoglobin and cell-free heme are toxic breakdown products of hemolyzed erythrocytes. Mammals synthesize the scavenger proteins haptoglobin and hemopexin, which bind extracellular hemoglobin and heme, respectively. Transfusion of packed red blood cells is a lifesaving therapy for patients with hemorrhagic shock. Because erythrocytes undergo progressive deleterious morphological and biochemical changes during storage, transfusion of packed red blood cells that have been… CONTINUE READING
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