Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque.

@article{Levy2007HaptoglobinGI,
  title={Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque.},
  author={Andrew P Levy and Joanne E. Levy and Shiri Kalet-Litman and Rachel Miller-Lotan and Nina S. Levy and Roy Asaf and Julia Guetta and Chingwen Yang and K. Raman Purushothaman and Valentin Fuster and Pedro Rolando Grandes Moreno},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 1},
  pages={134-40}
}
OBJECTIVE Intraplaque hemorrhage increases the risk of plaque rupture and thrombosis. The release of hemoglobin (Hb) from extravasated erythrocytes at the site of hemorrhage leads to iron deposition, which may increase oxidation and inflammation in the atherosclerotic plaque. The haptoglobin (Hp) protein is critical for protection against Hb-induced injury… CONTINUE READING