Haptoglobin genotype determines myocardial infarct size in diabetic mice.

  title={Haptoglobin genotype determines myocardial infarct size in diabetic mice.},
  author={Shany Blum and Roy Asaf and Julia Guetta and Rachel Miller-Lotan and Rabea Asleh and Ran Kremer and Nina S. Levy and Franklin G. Berger and Doron Aronson and Xiaoming Fu and Ruiting Zhang and Stanley L. Hazen and Andrew P Levy},
  journal={Journal of the American College of Cardiology},
  volume={49 1},
OBJECTIVES We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM). BACKGROUND Two common alleles (1 and 2) exist at the Hp locus in humans. The Hp 2 allele is associated with increased MI size in individuals with DM. In vitro, the Hp 2 protein is associated with increased generation of oxidatively active iron, whereas the Hp 1 protein is associated with increased production… CONTINUE READING


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