Haptoglobin genotype determines myocardial infarct size in diabetic mice.

@article{Blum2007HaptoglobinGD,
  title={Haptoglobin genotype determines myocardial infarct size in diabetic mice.},
  author={Shany Blum and Roy Asaf and Julia Guetta and Rachel Miller-Lotan and Rabea Asleh and Ran Kremer and Nina S. Levy and Franklin G. Berger and Doron Aronson and Xiaoming Fu and Ruiting Zhang and Stanley L. Hazen and Andrew P Levy},
  journal={Journal of the American College of Cardiology},
  year={2007},
  volume={49 1},
  pages={82-7}
}
OBJECTIVES We sought to understand the importance of oxidative stress in explaining why the haptoglobin (Hp) genotype determines myocardial infarction (MI) size in diabetes mellitus (DM). BACKGROUND Two common alleles (1 and 2) exist at the Hp locus in humans. The Hp 2 allele is associated with increased MI size in individuals with DM. In vitro, the Hp 2 protein is associated with increased generation of oxidatively active iron, whereas the Hp 1 protein is associated with increased production… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Haptoglobin gene polymorphism and oxidative stress effects on ovarian reserve in Beta-Thalassemia major women

Dr. Sally S. El Tawab, Dr. Nadia A. Sadek, Dr. Maher A. Kamel, Dr. Khaled S. Salem
2017

Marked protection against acute renal and hepatic injury after nitrited myoglobin + tin protoporphyrin administration.

Translational research : the journal of laboratory and clinical medicine • 2015
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Anti - inflammatory hemoglobin scavenging macrophages in atherosclerotic plaques : a potential atheroprotective role ( abstr )

P Philippidis, JP Boyle, J Domin
Circulation • 2005

The effect of vitamin E supplementation on cardiovascular risk in diabetic individuals with different haptoglobin phenotypes

AP Levy, H Gerstein, R Lotan
Diabetes Care • 2004

Similar Papers

Loading similar papers…