Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients

@article{Papp2006HaptoglobinPA,
  title={Haptoglobin Polymorphisms Are Associated with Crohn’s Disease, Disease Behavior, and Extraintestinal Manifestations in Hungarian Patients},
  author={M. Papp and P. Lakatos and K. Palatka and I. Foldi and M. Udvardy and J. H{\'a}rsfalvi and I. Tornai and Z. Vit{\'a}lis and T. Dinya and {\'A}. Kov{\'a}cs and T. Moln{\'a}r and P. Demeter and J. Papp and L. Lakatos and I. Altorjay and Hungarian Ibd Study Group},
  journal={Digestive Diseases and Sciences},
  year={2006},
  volume={52},
  pages={1279-1284}
}
Functional differences and association with inflammatory disorders were found relating to three major haptoglobin (Hp) phenotypes. Our aim was to investigate Hp polymorphisms in Hungarian patients with Crohn’s disease (CD). Four hundred sixty-eight CD patients and 384 healthy controls were examined. Hp phenotypes were determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting of the sera. The frequency of the Hp1 allele was significantly higher in CD (0.395; OR… Expand
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  • Biology, Medicine
  • Orvosi hetilap
  • 2008
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TLDR
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  • Medicine
  • Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 2008
TLDR
The present review brings this association with diseases that have inflammatory causes into perspective by looking at the functions of the protein and how defects in these functions associated with the Hp2 allele affect disease outcome. Expand
Polymorphism of human haptoglobin and its clinical importance
TLDR
This article summarizes the available data on the structure and functions of HP and the possible effects of Hp polymorphism in a number of important human disorders. Expand
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A significant association between PPAR&ggr; polymorphisms and the development of CD and UC at single loci level and also in haplotype combinations is demonstrated. Expand
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TLDR
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