Hapten-induced Colitis Is Associated with Colonic Patch Hypertrophy and T Helper Cell 2–Type Responses

@article{Dohi1999HapteninducedCI,
  title={Hapten-induced Colitis Is Associated with Colonic Patch Hypertrophy and T Helper Cell 2–Type Responses },
  author={Taeko Dohi and Kohtaro Fujihashi and Paul D. Rennert and Koichi Iwatani and Hiroshi Kiyono and Jerry R. Mcghee},
  journal={The Journal of Experimental Medicine},
  year={1999},
  volume={189},
  pages={1169 - 1180}
}
To investigate the potential involvement of T helper (Th)2-type responses in murine models of intestinal inflammation, we used trinitrobenzene sulfonic acid (TNBS)-hapten to induce inflammatory bowel disease in situations where Th1-type responses with interferon (IFN)-gamma synthesis are either diminished or do not occur. Intracolonic administration of TNBS to either normal (IFN-gamma+/+) or Th1-deficient IFN-gamma knockout (IFN-gamma-/-) BALB/c mice resulted in significant colitis. In IFN… CONTINUE READING