29 Citations
The case against psychiatric drugs
- Psychology, Medicine
- 2016
A close review of the scientific literature reveals a paradox: medications that are effective over the short term may increase the chronicity of a disorder over the long-term.
The case against antipsychotic drugs: a 50-year record of doing more harm than good.
- Psychology, MedicineMedical hypotheses
- 2004
The enigmatic phenotype: Relevant signs and symptoms in schizophrenia
- Psychology, Medicine
- 2005
It is concluded that the different approaches to the ordening of overt and covert symptoms in schizophrenia are essential analogue and that research into the delineation of cognitive deficits and their treatment is at present most promising.
The "delayed onset" of antipsychotic action--an idea whose time has come and gone.
- Psychology, MedicineJournal of psychiatry & neuroscience : JPN
- 2006
A body of data convincingly refutes the notion of "delay" in the onset of antipsychotic action and suggests an "early" onset instead and the implications for clinical decision-making, mechanisms of antip psychosis action and drug discovery are discussed.
Overview: Towards individualized treatment in schizophrenia
- Psychology, Medicine
- 2003
Findings in this work are consistent with the dopamine/serotonin hypothesis in schizophrenia and suggest that the continuous discovery of new gene variants and progressive methodological improvements will help elucidate the molecular pathological mechanisms in schizophrenia, and reveal new avenues for drug development research.
Differing response to antipsychotic therapy in schizophrenia: pharmacogenomic aspects
- Medicine, PsychologyDialogues in clinical neuroscience
- 2004
Pharmacogenomic investigations offer the opportunity to individualize antipsychotic therapy according to the growing knowledge of the function and effect of the genetic polymorphisms that affect the pharmacokinetics and pharmacodynamics of antipsychotics.
Characterization of the discriminative stimulus properties of the atypical antipsychotic amisulpride in C57BL/6 mice
- Psychology
- 2014
CHARACTERIZATION OF THE DISCRIMINATIVE STIMULUS PROPERTIES OF THE ATYPICAL ANTIPSYCHOTIC AMISULPRIDE IN C57BL/6 MICE By Timothy John Donahue, MS, MA, M.Ed. A dissertation submitted in partial…
An Overview of the Association between Schizotypy and Dopamine
- PsychologyFront. Psychiatry
- 2014
Data from published studies suggest that dopamine is important to the expression and experience of schizotypy and associated behavioral biases, and future studies are required to replicate individual observations, to enlighten the link between DA and different schizotypesy dimensions, and to guide the search for solid DA-sensitive behavioral markers.
Psychometric schizotypy modulates levodopa effects on lateralized lexical decision performance.
- PsychologyJournal of psychiatric research
- 2005
Re: Case Reports as Letters Should Stay in The Canadian Journal of Psychiatry
- Psychology, MedicineCanadian journal of psychiatry. Revue canadienne de psychiatrie
- 2005
A re-definition of subthreshold bipolarity: epidemiology and proposed criteria for bipolar-II, minor bipolar disorders and hypomania is proposed.
References
SHOWING 1-10 OF 63 REFERENCES
40 ans de neuroleptiques
- Psychology, Medicine
- 1993
The story of neuroleptics comprises three distinct periods: the discovery of several drugs and of their clinical effects occurred and was followed only a posteriori by definition, while the notions of refractory schizophrenia and of atypical neuroleptic have been described.
[40 years of neuroleptic drugs].
- Psychology, MedicineAnnales medico-psychologiques
- 1993
Since the Delay, Deniker and Harl's initial report, the story of neuroleptics comprises three distinct periods. Firstly the discovery of several drugs and of their clinical effects occurred and was…
[30 years later. The story of the discovery of neuroleptics].
- PsychologyAnnales medico-psychologiques
- 1982
The first trial use of neuroleptics for psychiatric purposes took place on 9 November 1951 at Villejuif psychiatric Hospital and the protocol drawn up during the session indicates the characteristic effects of chlorpromazine on the subject's emotional state.
Novel antipsychotics: issues and controversies. Typicality of atypical antipsychotics.
- Psychology, MedicineJournal of psychiatry & neuroscience : JPN
- 2000
New-generation neuroleptic agents were found to have greater efficacy on the negative symptoms of schizophrenia and to cause fewer unwanted extrapyramidal side effects than the traditional antipsychotic drugs.
Impact of neuroleptic chemotherapies on schizophrenic psychoses.
- Psychology, MedicineThe American journal of psychiatry
- 1978
The author reviews the impact of neuroleptic chemotherapy on various forms of schizophrenia in the 25 years since the introduction of chlorpromazine in psychiatry, with an emphasis on the "dual structure" of the illness.
Need for a new framework to understand the mechanism of all antipsychotics.
- Psychology, MedicineThe Journal of clinical psychiatry
- 2000
An schizophrenic patient who became resistant to 2 atypical neuroleptics but responded well to haloperidol in high doses is illustrated, as well as several clinical trials showing good efficacy on symptoms and a low propensity of EPS, which doesn’t fit very well with Remington and Kapur’s model.
The History of the Psychopharmacology of Schizophrenia
- Medicine, PsychologyCanadian journal of psychiatry. Revue canadienne de psychiatrie
- 1997
Effective treatment of schizophrenia was achieved only after the introduction of antipsychotic drugs, in the 1950s, and is still progressing, according to this review.
Commentary on "Clinical studies on the mechanism of action of clozapine; the dopamine–serotonin hypothesis of schizophrenia." Psychopharmacology (1989) 99:S18–S27
- Psychology, MedicinePsychopharmacology
- 2002
I was delighted and honored to learn from a recent editorial in Psychopharmacology (Miczek 2001) that my 1989 paper – Clinical studies on the mechanism of action of clozapine; the dopamine–serotonin…
Atypical antipsychotics
- Psychology, MedicineBMJ : British Medical Journal
- 2000
An infectious optimism has infused the field of schizophrenia with the availability of the new “atypical” antipsychotics, but sobering evidence is provided which questions this and suggests a large shift in prescribing practices in North America.
Clinical studies on the mechanism of action of clozapine: the dopamine-serotonin hypothesis of schizophrenia
- Psychology, MedicinePsychopharmacology
- 2004
It is proposed that schizophrenia may also involve a dysregulation of 5-HT2- and D-2-mediated neurotransmission, and that a more normal balance in serotonergic and dopaminergic neurotransmission is at least partially restored by clozapine.