Haplotypic analysis of the TNF locus by association efficiency and entropy

  title={Haplotypic analysis of the TNF locus by association efficiency and entropy},
  author={Hans Ackerman and Stanley Usen and Richard A Mott and Anna M. T. Richardson and Fatoumatta Sisay-Joof and Pauline Katundu and Terrie E. Taylor and Ryk Ward and Malcolm Edward Molyneux and Margaret Pinder and Dominic P Kwiatkowski},
  journal={Genome Biology},
  pages={R24 - R24}
To understand the causal basis of TNF associations with disease, it is necessary to understand the haplotypic structure of this locus. We genotyped 12 single-nucleotide polymorphisms (SNPs) distributed over 4.3 kilobases in 296 healthy, unrelated Gambian and Malawian adults. We generated 592 high-quality haplotypes by integrating family- and population-based reconstruction methods. We found 32 different haplotypes, of which 13 were shared between the two populations. Both populations were… CONTINUE READING

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