Haplotypes of Promoter and Intron 1 Polymorphisms in the COLIA1 Gene Are Associated with Increased Risk of Osteoporosis

@article{Husted2008HaplotypesOP,
  title={Haplotypes of Promoter and Intron 1 Polymorphisms in the COLIA1 Gene Are Associated with Increased Risk of Osteoporosis},
  author={Lise Bjerre Husted and Torben Harsl\of and N. Gonz{\'a}lez-Bofill and A. Schmitz and M. Cristie Carstens and Liselotte Stenkj{\ae}r and Bente Lomholt Langdahl},
  journal={Calcified Tissue International},
  year={2008},
  volume={84},
  pages={85-96}
}
Osteoporosis is a common age-related disease with a strong genetic influence. COLIA1 is one of the most extensively studied candidate genes and has consistently been associated with BMD and fracture. We examined the effects of the polymorphisms –1997G>T, –1663indelT, and +1245G>T and their haplotypes on vertebral fractures and bone mineral density (BMD) in… CONTINUE READING