Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance

@article{Ong2006HaplotypesIT,
  title={Haplotypes in the urotensin II gene and urotensin II receptor gene are associated with insulin resistance and impaired glucose tolerance},
  author={Kwok Leung Ong and Louisa Wong and Yu Bun Man and Raymond Y. H. Leung and Bernard Man Yung Cheung},
  journal={Peptides},
  year={2006},
  volume={27},
  pages={1659-1667}
}
We studied single nucleotide polymorphisms (SNPs) and haplotypes in the urotensin-II (UTS2) and urotensin-II receptor gene (UTS2R) in Hong Kong Chinese (224 hypertensive and 306 normotensive unrelated subjects) and their relation to hypertension and the metabolic syndrome. For UTS2, the GGT haplotype (-605G, 143G and 3836T) was associated with higher plasma level of U-II and insulin, and higher homeostasis model assessment of insulin resistance index and beta-cell function. For UTS2R, the AC… CONTINUE READING

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Urotensin II and the circulatory system

KL Ong, Cheung BMY
Hong Kong J Nephrol • 2005

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