Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.

  title={Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.},
  author={Ewa Zietkiewicz and Vania Yotova and Dominik Gehl and Tina Wambach and Isabel Arrieta and Mark A. Batzer and David E. C. Cole and Peter Hechtman and Feige Kaplan and David Laurence Modiano and Jean-Paul Moisan and Roman Michalski and Damian Labuda},
  journal={American journal of human genetics},
  volume={73 5},
Although Africa has played a central role in human evolutionary history, certain studies have suggested that not all contemporary human genetic diversity is of recent African origin. We investigated 35 simple polymorphic sites and one T(n) microsatellite in an 8-kb segment of the dystrophin gene. We found 86 haplotypes in 1,343 chromosomes from around the world. Although a classical out-of-Africa topology was observed in trees based on the variant frequencies, the tree of haplotype sequences… CONTINUE READING
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