Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.

@article{Zietkiewicz2003HaplotypesIT,
  title={Haplotypes in the dystrophin DNA segment point to a mosaic origin of modern human diversity.},
  author={Ewa Zietkiewicz and Vania Yotova and Dominik Gehl and Tina Wambach and Isabel Arrieta and Mark A. Batzer and David E. C. Cole and Peter Hechtman and Feige Kaplan and David Laurence Modiano and Jean-Paul Moisan and Roman Michalski and Damian Labuda},
  journal={American journal of human genetics},
  year={2003},
  volume={73 5},
  pages={
          994-1015
        }
}
Although Africa has played a central role in human evolutionary history, certain studies have suggested that not all contemporary human genetic diversity is of recent African origin. We investigated 35 simple polymorphic sites and one T(n) microsatellite in an 8-kb segment of the dystrophin gene. We found 86 haplotypes in 1,343 chromosomes from around the world. Although a classical out-of-Africa topology was observed in trees based on the variant frequencies, the tree of haplotype sequences… CONTINUE READING
Highly Cited
This paper has 69 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 33 extracted citations

X-chromosome lineages and the settlement of the Americas.

American journal of physical anthropology • 2009
View 8 Excerpts
Highly Influenced

Tracing genetic history of modern humans using X-chromosome lineages

Human Genetics • 2007
View 6 Excerpts
Method Support
Highly Influenced

70 Citations

051015'06'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 70 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 73 references

Archaic lineages

D Genet 61768–771 Labuda, E Ziętkiewicz, V Yotova
2000
View 19 Excerpts
Highly Influenced

Global patterns of human DNA sequence variation in a 10-kb region on chromosome 1.

Molecular biology and evolution • 2001
View 3 Excerpts
Highly Influenced

Modern human origins in light of the nuclear DNA diversity in world populations in P. In: Pres I (ed) Genes, fossils and behaviour: an integrated approach to human evolution

E Ziętkiewicz, D Labuda
2001
View 2 Excerpts
Highly Influenced

Arlequin version 1.1: a software for population genetic data analysis

S Schneider, J-M Kueffer, D Roessli, L Exoffier
Genetics and Biometry Laboratory, • 1997
View 1 Excerpt
Highly Influenced

Mitochondrial footprints of human expansions in Africa.

American journal of human genetics • 1997
View 4 Excerpts
Highly Influenced

The genetic clock

D Genet 31241–247 Labuda, E Ziętkiewicz, M Labuda
1997
View 5 Excerpts
Highly Influenced