Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease

@article{Borroni2007HaplotypesIC,
  title={Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease},
  author={Barbara Borroni and Mario Grassi and Chiara Costanzi and Mariella Zanetti and Alessandro Padovani},
  journal={Neurobiology of Aging},
  year={2007},
  volume={28},
  pages={1231-1238}
}
BACKGROUND The gene encoding catechol-O-methyltransferase (COMT) has been suggested as a candidate for Alzheimer-related psychosis (AD-P) susceptibility, and an association between AD-P and a functional valine to methionine polymorphism has been reported. OBJECTIVE The aim of this study was to assess the genetic contribution of other COMT variants to the risk of AD-P. METHODS Two hundred and forty-six AD patients underwent clinical and neuropsychological examination as well as an evaluation… CONTINUE READING

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