Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.

@article{Hennah2003HaplotypeTA,
  title={Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects.},
  author={William Hennah and T. Varilo and Marjo Kestil{\"a} and Tiina Paunio and Ritva Araj{\"a}rvi and Jari Haukka and Alex J. Parker and Rory Martin and Steve Levitzky and Timo Partonen and Joanne M. Meyer and Jouko L{\"o}nnqvist and L. Peltonen and J. Ekelund},
  journal={Human molecular genetics},
  year={2003},
  volume={12 23},
  pages={3151-9}
}
We have previously reported a linkage peak on 1q42 in a Finnish schizophrenia sample. In this study we genotyped 28 single nucleotide polymorphisms (SNPs) from 1q42 covering the three candidate genes TRAX, DISC1 and DISC2, using a study sample of 458 Finnish families ascertained for schizophrenia. Two-point and haplotype association analysis revealed a significant region of interest within the DISC1 gene. A common haplotype (HEP3) was observed to be significantly under-transmitted to affected… CONTINUE READING