Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients

@article{Nakajima2004HaplotypeSO,
  title={Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients},
  author={Yukiko Nakajima and Yoshiro Saito and Kisho Shiseki and Hiromi Fukushima-Uesaka and Ryuichi Hasegawa and Shogo Ozawa and Kenji Sugai and Masaaki Katoh and Osamu Saitoh and Teiichi Ohnuma and Mitsuru Kawai and Taisuke Ohtsuki and Chieko Suzuki and Narihiro Minami and Hideo Kimura and Yu-ichi Goto and Naoyuki Kamatani and Nahoko Kaniwa and Jun-ichi Sawada},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={61},
  pages={25-34}
}
Microsomal epoxide hydrolase (mEH) is an enzyme that detoxifies reactive epoxides and catalyzes the biotransformation of carbamazepine-10,11-epoxide (CBZ-epoxide) to carbamazepine-10,11-diol (CBZ-diol). Utilizing single nucleotide polymorphisms (SNPs) of the EPHX1 gene encoding mEH, we identified the haplotypes of EPHX1 blocks and investigated the association between the block haplotypes and CBZ-epoxide metabolism. SNPs of EPHX1 were analyzed by means of polymerase chain reaction amplification… CONTINUE READING
12 Citations
27 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Determination of probability distribution of diplotype configuration ( diplotype distribution ) for each subject from genotypic data using the EM algorithm

  • J Seidegard, JW DePierre
  • Ann Hum Genet
  • 2002

Determination of probability distribution of diplotype configuration (diplotype distribution) for each subject from genotypic data using the EM

  • Y Kitamura, M Moriguch, +4 authors N Kamatani
  • 2002
1 Excerpt

Similar Papers

Loading similar papers…