Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation.

@article{Alders2009HaplotypesharingAI,
  title={Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation.},
  author={Mari{\"e}lle Alders and Tamara T. Koopmann and Imke Christiaans and Pieter G. Postema and Leander Beekman and Michael W. T. Tanck and Katja Zeppenfeld and Peter Loh and Karel T. Koch and Sophie Demolombe and Marcel M. A. M. Mannens and Connie R. Bezzina and Arthur A. M. Wilde},
  journal={American journal of human genetics},
  year={2009},
  volume={84 4},
  pages={468-76}
}
Idiopathic Ventricular Fibrillation (IVF) is defined as spontaneous VF without any known structural or electrical heart disease. A family history is present in up to 20% of probands with the disorder, suggesting that at least a subset of IVF is hereditary. A genome-wide haplotype-sharing analysis was performed for identification of the responsible gene in three distantly related families in which multiple individuals died suddenly or were successfully resuscitated at young age. We identified a… CONTINUE READING