Haplotype reconstruction for scnp DNA: a consensus vote approach with extensive sequence data from populations of the migratory locust (Locusta migratoria).

@article{Huang2008HaplotypeRF,
  title={Haplotype reconstruction for scnp DNA: a consensus vote approach with extensive sequence data from populations of the migratory locust (Locusta migratoria).},
  author={Zu-Shi Huang and Ya-Jie Ji and De-Xing Zhang},
  journal={Molecular ecology},
  year={2008},
  volume={17 8},
  pages={1930-47}
}
Single copy nuclear polymorphic (scnp) DNA is potentially a powerful molecular marker for evolutionary studies of populations. However, a practical obstacle to its employment is the general problem of haplotype determination due to the common occurrence of heterozygosity in diploid organisms. We explore here a 'consensus vote' (CV) approach to this question, combining statistical haplotype reconstruction and experimental verification using as an example an indel-free scnp DNA marker from the… CONTINUE READING
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Molecular Cloning: A Laboratory Manual, 2nd edn

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