Haplotype inference from diploid sequence data: evaluating performance using non-neutral MHC sequences.

  title={Haplotype inference from diploid sequence data: evaluating performance using non-neutral MHC sequences.},
  author={D. H. Bos and S. Turner and J. A. DeWoody},
  volume={144 6},
  • D. H. Bos, S. Turner, J. A. DeWoody
  • Published 2007
  • Biology, Medicine
  • Hereditas
  • The direct sequencing of PCR products from diploid organisms is problematic because of ambiguities associated with phase inference in multi-site heterozygotes. Several molecular methods such as cloning, SSCP, and DGGE have been developed to empirically reduce diploid sequences to their constitutive haploid components, but in theory these empirical approaches can be supplanted by analytical treatment of diploid sequences. Analytical approaches are more desirable than molecular methods because of… CONTINUE READING
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