Haplotype inference from diploid sequence data: evaluating performance using non-neutral MHC sequences.

@article{Bos2007HaplotypeIF,
  title={Haplotype inference from diploid sequence data: evaluating performance using non-neutral MHC sequences.},
  author={D. H. Bos and S. Turner and J. A. DeWoody},
  journal={Hereditas},
  year={2007},
  volume={144 6},
  pages={
          228-34
        }
}
  • D. H. Bos, S. Turner, J. A. DeWoody
  • Published 2007
  • Biology, Medicine
  • Hereditas
  • The direct sequencing of PCR products from diploid organisms is problematic because of ambiguities associated with phase inference in multi-site heterozygotes. Several molecular methods such as cloning, SSCP, and DGGE have been developed to empirically reduce diploid sequences to their constitutive haploid components, but in theory these empirical approaches can be supplanted by analytical treatment of diploid sequences. Analytical approaches are more desirable than molecular methods because of… CONTINUE READING
    30 Citations
    Computation vs. cloning: evaluation of two methods for haplotype determination
    • 130
    Nuclear gene phylogeography using PHASE: dealing with unresolved genotypes, lost alleles, and systematic bias in parameter estimation
    • 119
    • PDF
    Adaptive molecular evolution of the Major Histocompatibility Complex genes, DRA and DQA, in the genus Equus
    • 37
    Inferring Population History and Demography Using Microsatellites, Mitochondrial DNA, and Major Histocompatibility Complex (MHC) Genes
    • 69
    • PDF
    Methods for MHC genotyping in non‐model vertebrates
    • W. Babik
    • Biology, Medicine
    • Molecular ecology resources
    • 2010
    • 129

    References

    SHOWING 1-10 OF 47 REFERENCES
    Haplotype inference in random population samples.
    • 197
    Inference of haplotypes from PCR-amplified samples of diploid populations.
    • A. Clark
    • Biology, Medicine
    • Molecular biology and evolution
    • 1990
    • 797
    • Highly Influential
    • PDF
    Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population.
    • 1,968
    • PDF
    A coalescence-guided hierarchical Bayesian method for haplotype inference.
    • 27
    • PDF
    Effectiveness of computational methods in haplotype prediction
    • 86
    • PDF
    Evolution and ecology of MHC molecules: from genomics to sexual selection.
    • 355
    • PDF