Haplotype diversity and SNP frequency dependence in the description of genetic variation

@article{Stumpf2004HaplotypeDA,
  title={Haplotype diversity and SNP frequency dependence in the description of genetic variation},
  author={Michael P. H. Stumpf},
  journal={European Journal of Human Genetics},
  year={2004},
  volume={12},
  pages={469-477}
}
Haplotype diversity is controlled by a variety of processes, including mutation, recombination, marker ascertainment and demography. Understanding the extent to which genetic variation at physically linked loci is co-inherited is crucial for the design of the HapMap project and the correct interpretation of the resulting data. In the absence of an analytical theory extensive coalescent simulations are used to disentangle the influence of all of these factors on haplotype diversity. In addition… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 25 references

Chromosomewide distribution of haplotype blocks and the role of recombination hot spots

  • MS Phillips, R Lawrence, R Schidanandam
  • Nat Genet
  • 2003

GAT: Estimating recombination rates from population-genetic data

  • Stumpf MPH, McVean
  • Nat Rev Genet 2003;
  • 2003

Similar Papers

Loading similar papers…