Haplotype block partition with limited resources and applications to human chromosome 21 haplotype data.

@article{Zhang2003HaplotypeBP,
  title={Haplotype block partition with limited resources and applications to human chromosome 21 haplotype data.},
  author={Kui Ting Zhang and Fengzhu Sun and Michael S. Waterman and Ting Chen},
  journal={American journal of human genetics},
  year={2003},
  volume={73 1},
  pages={
          63-73
        }
}
Recent studies have shown that the human genome has a haplotype block structure such that it can be decomposed into large blocks with high linkage disequilibrium (LD) and relatively limited haplotype diversity, separated by short regions of low LD. One of the practical implications of this observation is that only a small fraction of all the single-nucleotide polymorphisms (SNPs) (referred as "tag SNPs") can be chosen for mapping genes responsible for human complex diseases, which can… CONTINUE READING
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