Haplotype association of IL-8 gene with Behcet's disease.

  title={Haplotype association of IL-8 gene with Behcet's disease.},
  author={Eun Bong Lee and J Y Kim and J-j Zhao and Myoung Hee Park and Yeong Wook Song},
  journal={Tissue antigens},
  volume={69 2},
Interleukin-8 (IL-8), a CXC chemokine that recruits and activates inflammatory cells, plays a critical role in the pathogenesis of Behcet's disease (BD). To investigate the association of the genetic polymorphism of IL-8 and BD, we genotyped IL-8 -845 T/C, -738 T/A, -353 A/T, -251 A/T, +293 G/T, +678 T/C and receptors CXCR-1 +2607 G/C and CXCR-2 +785 C/T polymorphisms in 119 Korean patients with BD and 119 age- and sex-matched healthy blood donors. Then, single nucleotide polymorphisms (SNPs… CONTINUE READING