Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies.

@article{Feigelson2006HaplotypeAO,
  title={Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies.},
  author={Heather Spencer Feigelson and David G. Cox and Howard M. Cann and Sholom Wacholder and Rudolf Kaaks and Brian E. Henderson and Demetrius Albanes and David Altshuler and Goran Berglund and Franco Berrino and Sheila Anne Bingham and Julie E. Buring and No{\"e}l P. Burtt and Eugenia E. Calle and Stephen J. Chanock and Francoise Clavel-Chapelon and Graham A. Colditz and W Ryan Diver and Matthew L. Freedman and Christopher A. Haiman and Susan E. Hankinson and Richard B Hayes and Joel Hirschhorn and David J. Hunter and Laurence N. Kolonel and Peter Kraft and Loic Lemarchand and Jakob P Linseisen and William S. Modi and Carmen Navarro and P. H. Peeters and Malcolm C. Pike and Elio Riboli and Veronica Wendy Setiawan and Daniel O. Stram and Gilles Thomas and Michael J. Thun and Anne Tjonneland and Dimitirios Trichopoulos},
  journal={Cancer research},
  year={2006},
  volume={66 4},
  pages={2468-75}
}
The 17beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17HSD1, which catalyzes the final step of estradiol biosynthesis. Despite the important role of HSD17B1 in hormone metabolism, few epidemiologic studies of HSD17B1 and breast cancer have been conducted. This study includes 5,370 breast cancer cases and 7,480 matched controls from five large… CONTINUE READING