Haplotype analysis of the CETP gene: not TaqIB, but the closely linked -629C-->A polymorphism and a novel promoter variant are independently associated with CETP concentration.

@article{Klerkx2003HaplotypeAO,
  title={Haplotype analysis of the CETP gene: not TaqIB, but the closely linked -629C-->A polymorphism and a novel promoter variant are independently associated with CETP concentration.},
  author={Anke H E M Klerkx and Michael W. T. Tanck and John J. P. Kastelein and Henri O. F. Molhuizen and Jan Wouter Jukema and Aeilko H. Zwinderman and Jan A. Kuivenhoven},
  journal={Human molecular genetics},
  year={2003},
  volume={12 2},
  pages={111-23}
}
The TaqIB polymorphism in intron 1 of the cholesteryl ester transfer protein (CETP) gene is associated with plasma CETP concentration, high-density lipoprotein cholesterol (HDL-C) and coronary artery disease (CAD). These associations are generally thought to arise from linkage disequilibrium between TaqIB and (an)other functional polymorphism(s). To identify putative functional sites, we investigated phenotypic associations of TaqIB and four tightly linked polymorphisms (novel -2708G-->A and… CONTINUE READING
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